Head:
Rafael Luque Alvarez de Sotomayor
PhD, Dr., Professor at the University of Cordoba, Spain. In 2020, Rafael Luque was named Highly Cited Researchers (Top 1%) by Clarivate Analytics.
Structural unit: Faculty of Science.
The laboratory conducts research on developing methods for producing biologically active substances using modern resource-saving technologies. The laboratory also serves as a training facility for students enrolled in the English-language Master's program in Bioenergies and Biorefineries.
Resourses
The laboratory base allows to carry out:
- Experiments under microwave activation
- Electrochemical synthesis
- Flow reactions
- Visible light-mediated chemistry
Equipment fleet
- OU SHISHENG high-performance flow reactors with photochemical transformation capabilities
- Preekem NOVA-2S microwave synthesis system
- Laboratory equipment for synthetic work
- PICASO 3D Designer X PRO S2 (Series 2) 3D printers
The laboratory team is developing methods for synthesizing biologically active substances using flow synthesis, electrochemical methods, and studying reactions under microwave activation conditions.
Partners
- Wuhan University of Technology
- N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
Contacts
Associate Professor of the Department of Organic Chemistry
Alexey A. Festa
festa-aa@rudn.ru
- Biomass processing and creation of substances with increased value: production and use of biofuels and new materials
- Use of flow synthesis for the production and modification of medicinal substances
- Employment of microwave-enhanced organic synthesis
- Research of visible light-mediated for chemical reactions
- Electrochemical synthesis and functionalization of biologically active substances
A sensitive and easy-to-use dual fluorescence-colorimetric platform based on the peroxidase-like activity of the MAX phase Fe2AlB2 has been developed for the detection of the pesticides acetamiprid and imidacloprid. This system enables rapid and accurate analysis of pesticide content in water and agricultural products. The developed methodology has potential for application in environmental protection, food quality control, and public health safety.
An environmentally friendly method for the synthesis of coumarins via the Pechmann reaction has been developed using functionalized organosilicate catalysts based on pyridinium ionic liquids (PMO-Py-IL). This approach aims to improve the efficiency and environmental friendliness of the process for producing coumarins, which are important compounds with a wide range of applications in pharmaceuticals, food, cosmetics, and other fields. The methodology for obtaining the target products is characterized by high yields, mild process conditions, and does not require the use of toxic solvents.
A novel continuous-flow Sonogashira coupling protocol has been developed that operates efficiently at room temperature. Using the E-FLOW-10 platform, the researchers optimized a catalytic system based on palladium acetate, copper iodide, and triphenylphosphine. A key innovation was the strategic separation of the palladium and copper catalysts into two streams, effectively preventing the rapid precipitation of palladium metal and significantly improving catalytic performance and process stability.