Researchers conducted a systematic review of articles that analyzed the effect of medicine remedies used to treat COVID-19 during pregnancy.
Researchers conducted a search between 1st of January and 5th of May, 2020, using the keywords “COVID-19,” “SARS-CoV-2,” “pregnancy,” and “therapy.” The analysis covered only drugs with presumptive effects on COVID-19 whose safe use during pregnancy has been proven by clinical trials in other infectious diseases. Drugs contraindicated in pregnancy or with unknown side effects were not included in this review.
“Pregnant women are a high-risk group for coronavirus complications. The situation is also complicated by the fact that not all medications can be prescribed to pregnant women due to their possible teratogenic effect on the fetus, which poses new challenges for the development of effective and safe medications for this category of COVID-19 patients”, — Anna Borisova, Ph.D. in Medicine, assistant of the Department of Obstetrics and Gynecology, Institute of Medicine, RUDN.
As a result of the study, scientists identified groups of drugs that can be used to treat COVID-19 during pregnancy, as well as indications for their prescription:
- Antiviral medications: lopinavir, ritonavir, remdesivir.
- Antimalarial medications: hydroxychloroquine.
- Anticoagulants medications: Low-molecular-weight heparin (due to increased risk of thromboembolic complications in patients with COVID-19).
- Steroids medications: betamethasone (to accelerate fetal lung maturation, since SARS-CoV-2 infection during pregnancy, especially in the third trimester, may increase the risk of premature rupture of fetal membranes and premature birth).
- Antibacterials medications: amoxicillin, azithromycin, ceftriaxone (must be prescribed only if a bacterial infection is suspected).
- Metformin and statins (can be used as adjuvant therapy, to reduce the required dose of antiviral medication and, therefore, its side effects).
- Reconvalescent plasma (antibodies contained in the plasma of convalescents reduce the viral load, the severity of the disease, and improve aeration).
- Immunomodulators medications, such as tocilizumab.
- Interferon type I.
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The RUDN University Science and Innovation Prize winners were honoured at the extended meeting of the Academic Council. In 2024 the terms of the traditional RUDN University Prize were changed: for the first time the competition was announced in two categories: leading scientists and young scientists.
According to the International Energy Agency (IEA), electricity consumption in Africa has increased by more than 100% over the past two years (2020-2022). However, 74.9% of this energy is still produced by burning organic fuels 鈥� natural gas, coal and oil. At the same time, the level of electrification on the continent remains extremely low 鈥� only 24%, while in other developing countries it reaches 40%. Even in grid-connected areas, electricity supply is often unreliable: industrial enterprises lose energy on an average of 56 days a year.
Today, diagnosis and treatment planning with orthodontists takes several days. Also, complications can arise during treatment that slow down the patient's recovery process. For example, improper orthodontic treatment planning can lead to temporomandibular joint dysfunction.